Peter attempts to re-connect with Mary Jane, but she informs him it is too late.
Aunt May and Peter reconcile, and she tells Peter of the hope that Spider-Man brings to others, in spite of what dreams he may have to sacrifice. Back home, after visiting Uncle Ben's grave, Aunt May is distressed by Peter's confession that he was somewhat responsible for his Uncle Ben's death. Jonah Jameson is delighted, having been given the abandoned Spider-Man suit. Peter questions if he could ever have what he "needs", a life as Peter Parker, which involves a vision of Uncle Ben, and resolves to give up being Spider-Man, to which J. Meanwhile, Octavius rebuilds his experimental reactor. He also gets into a physical altercation with Harry, who is drunk because Octavius' failed experiment left Oscorp bankrupt shortly after, Peter loses his powers while web-slinging across town he is unable to spin webs, his ability to adhere to smooth surfaces fails and his spider sense is greatly diminished. Jonah Jameson's son, John Jameson, an astronaut. When Spider-Man rescues her, she revises her former opinion of him and realizes that he is a hero. After a short glitch in his powers, Spider-Man manages to recover and soon the two take their fight outside the bank where Doc Ock takes Aunt May as a hostage. In an effort to finance his experiments, Doc Ock attempts to rob a bank where Peter Parker and his Aunt May happen to be present. Jonah Jameson names him "Doctor Octopus" or "Doc Ock". Uncontrolled, the tentacles begin to corrupt Octavius' mind, playing on his vanity and ego, and he decides he must complete his experiment at any cost. Unconscious, he is taken to a hospital to have the appendages removed, but the tentacles develop their own ability to move at will and brutally kill the surgeons, and Octavius escapes. Octavius refuses to halt it, with devastating results: his wife is killed the neural inhibitor chip which prevented the advanced AI of the arms from influencing Octavius's own mind is destroyed and the arms become fused to his spine. Though the experiment overloads and becomes unstable, Dr. To perform a sustained fusion experiment, Octavius has developed a set of artificially intelligent mechanical arms, which are impervious to heat and magnetism. Harry, now head of Oscorp's research division, has invested in the research of brilliant scientist Otto Octavius, Peter's idol. Moreover, he has become estranged from both love interest Mary Jane, who to Peter's disappointment is in a relationship, and best friend Harry Osborn who falsely accuses Spider-Man of murdering his father, and his Aunt May is threatened with foreclosure. He loses a job delivering pizzas in Manhattan, faces financial difficulties, and struggles to maintain his physics studies at Columbia University. Precariously struggling to balance his crime-fighting duties as Spider-Man with the demands of his normal life, Peter often finds his personal life taking a back seat. Peter Parker is finding his double life increasingly difficult.The synopsis below may give away important plot points.